The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in …
AD Bailey, LT Gray, T Pavelitz, JC Newman, K Horibata… - DNA repair, 2012 - Elsevier
Cockayne syndrome is a segmental progeria most often caused by mutations in the CSB
gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR).
Over 43Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable
element integrated into intron 5 of the CSB gene. As a result, primate CSB genes now
generate both CSB protein and a conserved CSB-PGBD3 fusion protein in which the first 5
exons of CSB are alternatively spliced to the PGBD3 transposase. Using a host cell …
gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR).
Over 43Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable
element integrated into intron 5 of the CSB gene. As a result, primate CSB genes now
generate both CSB protein and a conserved CSB-PGBD3 fusion protein in which the first 5
exons of CSB are alternatively spliced to the PGBD3 transposase. Using a host cell …
